Recovering alcoholic, Lee Baldwin, started to date nurse Jessie Brewer who was trying to get over her painful marriage to Phil Brewer. On the seventh floor of General Hospital Lee volunteered as an addiction counselor.

After Phil left town Jessie discovered that she was pregnant with his baby. Lee offered Jessie marriage so that her baby would have a name and a father. Jessie accepted but before her divorce could be finalized and she could marry Lee, Phil found out that she was carrying his child and he returned to Port Charles. Phil begged for forgiveness and asked for a month to make things right for him and Jessie. Jessie was afraid that if she went back to Phil that Lee would return to his drinking habits. So instead of forgiving Phil she decided to go through with the wedding. But the night before the wedding Jessie went into labor. Since the divorce hadn't been finalized the baby was born under the last name of Brewer, which made Phil happy.

Jessie gave birth to a daughter which she named Nancy. Lee then told Jessie that he was freeing her from the engagement. But in 1966 Nancy died from a bad heart condition.

That same year, nurse Meg Bently joined General Hospital. Meg, a widow with a son name Scotty and a stepdaughter had to maintain a platonic relationship with Lee because she was engaged to Dr. Noel Clinton at the time. But the engagement wouldn't last long since Noel was more interested in Meg's stepdaughter Brooke. And soon after Noel told Meg that the engagement was off because he was leaving her for Brooke. Meg was shocked and devastated and was comforted by Lee.

Scotty was also very upset over this. He now lost his sister and the man he wanted to be his father. Noel and Brooke ran off and eloped. Lee started acting like a father to young Scotty. In late 1966 a joyful Meg married Lee.

When Jessie was charged with the murder of her late husband Dr. John Prentice Lee was her attorney. Unfortunately, Lee had lost the case and Jessie was sent to jail. But soon after Jessie's stepdaughter Polly confessed to the murder freeing Jessie.

In 1969 Meg's old nursing school friend Iris Fairchild came to town and was also an alcoholic. Lee still counseling people at the hospital got Iris to quit drinking and got her a job as a secretary. This made Meg jealous and then she accused Lee and Iris of having an affair. This caused Lee and Meg to split up. But their time away from each other wasn't long because they reunited after Lee donated one of his kidneys to Scotty and saved his life.

Brooke returned to live with her stepmother and Lee after her marriage to Noel had gone down the drain. That same year Meg was diagnosed with breast cancer. She had to under go a mastectomy. Meg then became insure about her appearance to her stepdaughter Brooke. Meg then had a nervous breakdown from the jealousy and depression. Lee was forced to institutionalize his wife.

In 1971 Meg returned to Port Charles which thrilled Lee. Supposedly Meg had recovered from her nervous breakdown. But Meg now had a bad case of Hypertension and a young Dr. Lesley Williams was assigned to Meg's case. Because of her jealousy Meg believed Lesley was trying to pursue Lee. And Meg confronted Lee with her false accusations. But during an argument Meg had a stroke and died instantly. A devastated Lee remained strong for his son Scotty.

Again Lee defended Jessie when she was charged with the murder of her former husband Phil Brewer in 1974. When Jessie refused to cooperate in her defense Lee encouraged her to fight the false charges and then he passionately kissed her. Lee proved that Jessie was innocent but they couldn't get what they had back.

Lee finally found a soul mate when he met social worker Caroline Chandler. They married and had a short honeymoon. But upon returning from their honeymoon they got the heart breaking news that Caroline's son Bobby had an incurable disease called Malakoff's disease. But soon after Dr. Steve Hardy found that the diagnosis was wrong. After the great news Lee and Caroline moved to New York City with Bobby and his pregnant wife Samantha.

In 1977 Lee returned to Port Charles after Caroline and Bobby were lost at sea. Lee was comforted by his platonic relationship with Dr. Gail Adamson. Gail had sensed Lee's devastation and unbeknownst to Lee Gail contacted Scotty who was in law school and living Greenwich Village, New York City. Scotty reunited with his father and Gail was thrilled that her plan had worked. Scotty agreed to stay in town and got a job at General Hospital as a hospital clerk. There he met and felt instantly attracted to Laura Webber.

In 1979 Scotty had planned to marry Laura but as the time went by she lost confidence and broke off their engagement. A devastated Scotty turned his pain over to alcohol and began on the same path his recovering stepfather had gone down. But luckily Lee pulled his son out of that addiction.

In 1980 Gail and Lee married and their lives were now revolving around Scotty's marriage problems to Laura Webber. When Laura wanted to divorce Scotty, Lee burned the divorce papers.

In 1983 Lee ran for mayor and his opponent was Luke Spencer, the man who destroyed Scotty and Laura's marriage. Scotty who was his father's campaign manager try to discredit Luke using any information he could get on him. Scotty threatened Luke that he would expose his sister Bobbie's history as a prostitute if Luke didn't drop out of the race. Once Lee found out what Scotty was doing he fired his son as his campaign manager. Scotty then left town and Luke won the election.

In 1994 Lee and Gail found out that they were, in fact, grandparents. They were shocked to learn that young Karen Wexler was their granddaughter. She was conceived when Scotty had an affair with his secretary Rhonda Wexler while attending law school.

In 1997 Scotty returned to Port Charles with his daughter Serena Baldwin. Lee and Gail were thrilled to see Scotty and to see their other granddaughter again.

In 1998 Lee defended Dr. Julie Lambert when she was charged with the General Homicide serial killings. When the trial began Lee tried to make Dr. Eve Lambert look like the guilty one. His defense was a success and Julie was acquitted.

The killer was still free and now the police had evidence to who the killer might be which was caught on the surveillance camera on the roof of General Hospital. The killer wore a wig that resembled Eve's hair, but when she stood at a mirror and her face was revealed it turned out that Julie Devlin-Morris was the killer.

Julie was being controlled by Dr. Greg Cooper. When Julie was caught, Lee became her legal guardian and Gail would stop it nothing to get Julie committed to Ferncliff where she would get the treatment she needed.

Lee suffered a pulmonary embolism in 1999. Everyone was devastated by this especially Gail. Lee nearly died, but with the love and care of his loved ones he finally pulled through and recovered.

In 2003 Lee and Gail were devastated when hearing that their granddaughter Karen was killed after being hit by a car. Although they had lost their granddaughter they were happy to know that her blood had saved Lucy Coe's life.

When Lila Quartermaine passed away in her sleep, Lee and Gail went to the funeral where they paid their respects.